Mouse IL-1 beta Precoated ELISA Kit
$499.00
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Key Features
✓ Assay Range: 31.3-2000 pg/mL
✓ Sensitivity: 22 pg/mL
✓ Sample Types: Serum, Plasma, Cell Culture Supernates
Size
✓ 1 Kit (96 well plate)
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Product Details
Storage & Preparation
Data Images
Background
Product Documents
Product Details
| Product Type | Quantitative ELISA, Colorimetric |
| Product Summary |
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| Reactivity | Mouse IL-1 beta
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| Product Components |
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Storage & Preparation
| Shipping | Shipped on blue ice |
| Stability & Storage | Store the unopened kit at 2-8℃, The kit is stable for 12 months. Do not use beyond expiration date. |
| Reconstitution | See Datasheet for Component Preparation |
Data Images
Mouse IL-1 beta ELISA standard curve, typical data. User-generated standard curve is required for each set of samples. Please refer to protocol.
Background
| Alternative Names | Interleukin 1 beta, IL1B, IL1F2, Catabolin, IFN beta Inducing Factor, Osteoclast Activating Factor, OAF |
| Function | Interleukin-1 beta (IL-1 beta) is a pro-inflammatory cytokine that mediates inflammation and triggers other cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). IL-1 beta helps regulate the immune response by activating immune cells such as T cells (Th1 and Th17), B cells, and macrophages. It enhances the antigen-presenting function of antigen-presenting cells (APCs). IL-1 beta has pyrogenic effects triggered through the hypothalamus. In cell culture, IL-1 beta maintains the survival of mesenchymal stromal cells and hematopoietic progenitor cells and stimulates the differentiation of mesenchymal stem cells and neural stem cells. IL-1beta signaling is triggered by binding to IL-1RI following by association with the accessory protein, IL-1 RAcP. IL-1 beta signaling is modulated by binding to two decoy receptors a soluble IL-1Ra or membrane-bound IL-1RII. |
| Tissue Specificity | IL-1 beta expression has been identified in endothelial tissue, skin, lungs, gastrointestinal tissue, microglia, astrocytes, neurons, and adipose tissue. |
| Cellular Localization | Secreted protein |
| Involvement in Disease | Dysregulation of IL-1 beta is associated with inflammatory disorders (Cryopyrin-Associated Periodic Syndromes (CAPS), Neonatal-Onset Multisystem Inflammatory Disease (NOMID)), autoimmune disorders (Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE), Inflammatory Bowel Disease (IBD)), osteoarthritis, Juvenile Idiopathic Arthritis (JIA), psoriasis, dermatitis, Alzheimer’s Disease, Parkinson’s Disease, Multiple Sclerosis (MS), Type 2 Diabetes, Obesity, myocardial infarction, atherosclerosis and cancers by promoting inflammation in the tumor microenvironment and metastasis. |
| UniProt | P10749 |
| Gene Symbol | IFNG |
| Entrez Gene ID | 16176 |
Product Documents
| Product Datasheet | Download Product Datasheet |
| COA | Contact Us |
| SDS | Contact Us |
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