Recombinant Cytokines and Growth Factors for Cell Culture
Biologically active cytokines and growth factors are essential for activating, expanding, and differentiating your cells. Our recombinant cytokines support a wide range of cell types, including stem cells, neural cells, immune cells, and organoids. Enhance your research in immunotherapy, stem cell therapy, and regenerative medicine with our high-quality products.
Cytokines are secreted by certain cells of the immune system and bind to specific receptors on the surface of their target cells. This binding triggers intracellular signaling pathways that upregulate or downregulate gene expression, cell proliferation, differentiation, migration, and cell death. Cytokines play a crucial role in the immune response and inflammation. In a similar manner, growth factors play a role in regulating cellular growth, proliferation, differentiation, and survival.Â
Understanding the roles of cytokines and growth factors is crucial for elucidating the mechanisms of normal systemic responses, as well as the dysregulation that leads to disease development. This knowledge also informs strategies for potential therapeutic targets.Â
Exceptional Recombinant Proteins
- Highly-bioactive proteins: validated in relevant bioassays
- High purity
- Low endotoxin levels
- Rigorous Quality Control: consistent and reproducible results between lots
- Developed in-house: full control of all processes at our facility in Minneapolis, MN, USA.
Benchmark Testing With Top Suppliers
As part of our recombinant cytokine and growth factor product design and quality control process, we routinely benchmark our product specifications with other suppliers. Our goal is to match or exceed the specifications of top suppliers.
The three figures below show a comparison of Expreprotein Recombinant Human GDNF Protein (Catalog # EXRP036) with a version from two other suppliers. All three figures reflect the Exreprotein product with similar or better specifications for bioactivity (Figure 1), protein purity determined by SDS-PAGE (Figure 2), and endotoxin unit (EU) per 1 µg threshold (Figure 3).
Detailed Specifications on Datasheets and Product Webpages
Figure A. Recombinant Mouse TNF-alpha (Catalog # EXRP010) bioactivity determined by a cytotoxicity assay using L-929 mouse fibroblast cells in the presence of actinomycin D. The ED50 for this effect is typically 10-40 pg/mL.
Figure B. Recombinant Mouse TNF-alpha (Catalog # EXRP010) purity is tested on SDS-PAGE under reducing (R) conditions. The gel was stained using Coomassie® Blue showing purity greater than 95%.Â
Bulk Sizes
Custom Protein Expression and Purification
Leverage our expertise in protein development for your next custom protein project. We will collaborate with you to define the scope and requirements, from cloning and expression to purification, quality control, and delivery of the final product. We offer multiple expression platforms and can scale up production to bulk quantities, all from our facility in Minneapolis, Minnesota. Learn more.
