Product Type	Quantitative ELISA, Colorimetric
Product Summary	Assay Range: 7.8-500 pg/mL Sensitivity: 5 pg/mL Sample Types: Serum, Plasma, Cell Culture Supernates Intra-Assay Precision: ≤10% Inter-Assay Precision: ≤15%
Reactivity	Human CCL17/TARC No cross-reactivity with human cytokines
Product Components	Human CCL17/TARC Coated Microplate, 96 well (8 x12 strips) Human CCL17/TARC Standard, 2 vials Human CCL17/TARC Biotinylated Antibody, 2 vials Streptavidin-HRP, 2 vials Dilution Buffer, 3 bottles Washing Buffer, 1 bottle Color Reagent (TMB), 1 bottle Stop Solution, 1 bottle Plate Sealers, 4 strips Other materials required: See Datasheet

Shipping	Shipped on blue ice
Stability & Storage	Store the unopened kit at 2-8℃, The kit is stable for 12 months. Do not use beyond expiration date.
Reconstitution	See Datasheet for Component Preparation

Alternative Names	CCL17, TARC, ABCD-2, SCYA17, C-C Motif Chemokine 17, Small-inducible Cytokine A17, T cell-directed CC chemokine, Thymus and Activation-regulated Chemokine
Function	TARC, also known as, CCL17, is a member of the CC chemokine family primarily functioning in a chemotactic role with T lymphocytes (especially Th2 cells), dendritic cells, and regulatory T cells, toward sites of inflammation or lymphoid tissues. TARC binds to chemokine receptor CCR4, a G protein-coupled receptor (GPCR), which is expressed on immune cells including Th2 cells, regulatory T cells, and some dendritic cell subsets. Upon binding TARC, CCR4 undergoes a conformational change that activates intracellular heterotrimeric G proteins leading to inhibition of Adenylyl Cyclase and activation of MAP kinases (ERK1/2) to drive chemotaxis.
Tissue Specificity	TARC is expressed in various tissues related to its role in immune responses, such as thymus tissue, lymph nodes, spleen, skin (Langerhans cells), lung tissue (bronchial epithelial cells), liver tissue, kidney tissue and the gastrointestinal tract.
Cellular Localization	Secreted protein
Involvement in Disease	Dysregulation of TARC is implicated in allergy (atopic dermatitis and asthma), autoimmune disorders (rheumatoid arthritis and inflammatory bowel disease), and Hodgkin lymphoma.
UniProt	Q92583
Gene Symbol	CCL17
Entrez Gene ID	6361

Human CCL17/TARC Precoated ELISA Kit

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