Human IFN-alpha Precoated ELISA Kit
$499.00
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Key Features
✓ Assay Range: 7.8-500 pg/mL
✓ Sensitivity: 5 pg/mL
✓ Sample Types: Serum, Plasma, Cell Culture Supernates
Size
✓ 1 Kit (96 well plate)
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Product Details
Storage & Preparation
Data Images
Background
Product Documents
Product Details
| Product Type | Quantitative ELISA, Colorimetric |
| Product Summary |
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| Reactivity | Human IFN-alpha
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| Product Components |
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Storage & Preparation
| Shipping | Shipped on blue ice |
| Stability & Storage | Store the unopened kit at 2-8℃, The kit is stable for 12 months. Do not use beyond expiration date. |
| Reconstitution | See Datasheet for Component Preparation |
Data Images
Human IFN-alpha ELISA standard curve, typical data. User-generated standard curve is required for each set of samples. Please refer to protocol.
Background
| Alternative Names | Interferon alpha, IFL, LelFD, Interferon alpha-D, IFN-alpha-D, Interferon alpha-A, IFN-alpha-A, Interferon alpha 2a, IFN-alpha 2a, Interferon alpha 2b, IFN-alpha 2b, Interferon alpha 1, IFN-alpha 1 |
| Function | IFN‑alpha is a cytokine playing establish an antiviral state but also modulates the immune system and controls cell proliferation through a well-orchestrated receptor-mediated signaling pathway. Multiple IFN‑alpha subtypes exist, with varying degrees of amino acid sequence homology that is thought to affect the distinct biological activities in terms of interacting with the shared receptor, IFNAR. IFNAR is a heterodimer composed of two subunits, IFNAR1 and IFNAR2. Upon binding to IFNAR, IFN‑alpha triggers the activation of associated Janus kinases (JAK1 and TYK2). These kinases phosphorylate signal transducer and activator of transcription (STAT) proteins, primarily STAT1 and STAT2. Phosphorylated STAT1 and STAT2 form a complex with IRF9, creating the interferon-stimulated gene factor 3 (ISGF3). |
| Tissue Specificity | IFN‑alpha is not constitutively expressed at high levels by most cells but is rapidly upregulated in response to viral infection or other immune triggers. IFN-alpha expression has been reported in plasmacytoid dendritic cells (pDCs), monocytes, macrophages, fibroblasts, and epithelial cells. IFN-alpha expression has also been reported in lymphoid tissues (lymph nodes, spleen, bone marrow). |
| Cellular Localization | Secreted protein |
| Involvement in Disease | Dysregulation of IFN-alpha is reported in autoimmune diseases (systemic lupus erythematosus, rheumatoid arthritis and Sjogren’s syndrome), Type I Interferonopathies (Aicardi-Goutieres syndrome [AGS] and STING [STING-associated vasculopathy with onset in infancy]), and chronic viral infections. |
| UniProt | P01562 |
| Gene Symbol | IFNA1 |
| Entrez Gene ID | 3439 |
Product Documents
| Product Datasheet | Download Product Datasheet |
| COA | Contact Us |
| SDS | Contact Us |
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