Product Type	Quantitative ELISA, Colorimetric
Product Summary	Assay Range: 62.5-4000 pg/mL Sensitivity: 31.3 pg/mL Sample Types: Serum, Plasma, Cell Culture Supernates Intra-Assay Precision: ≤10% Inter-Assay Precision: ≤15%
Reactivity	Human IL-17A No cross-reactivity with human cytokines
Product Components	Human IL-17A Coated Microplate, 96 well (8 x12 strips) Human IL-17A Standard, 2 vials Human IL-17A Biotinylated Antibody, 2 vials Streptavidin-HRP, 2 vials Dilution Buffer, 3 bottles Washing Buffer, 1 bottle Color Reagent (TMB), 1 bottle Stop Solution, 1 bottle Plate Sealers, 4 strips Other materials required: See Datasheet

Shipping	Shipped on blue ice
Stability & Storage	Store the unopened kit at 2-8℃, The kit is stable for 12 months. Do not use beyond expiration date.
Reconstitution	See Datasheet for Component Preparation

Alternative Names	Interleukin-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA8
Function	IL-17A is a pro-inflammatory cytokine primarily produced by T helper 17 (Th17) cells, as well as by other immune cells such as gamma-delta T cells and group 3 innate lymphoid cells (ILC3s). The functional homodimer exerts its effects by binding to a receptor complex composed of the IL-17RA and IL-17RC subunits. Upon ligand binding, the receptor recruits the adaptor protein ACT1 (also known as CIKS). The ACT1 adaptor facilitates the activation of the NF-kappa B pathway, leading to the transcription of numerous pro-inflammatory genes. In addition to NF-kappa B, IL-17A signaling triggers MAPK cascades (such as ERK, JNK, and p38 pathways), which further amplify the inflammatory response via inflammatory cytokines and chemokines, such as IL-6 and IL-8.
Tissue Specificity	IL-17A is expressed by several immune cell types—most notably Th17 cells, gamma-delta T cells, and ILC3s—and is predominantly found in secondary lymphoid organs, mucosal surfaces (such as the gut, lung, and skin), and sites of inflammation.
Cellular Localization	Secreted
Involvement in Disease	Dysregulation of IL-17A has been reported in inflammatory and autoimmune diseases (psoriasis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, ankylosing spondylitis, asthma, systemic lupus erythematosus).
UniProt	Q16552
Gene Symbol	IL17A
Entrez Gene ID	3605

Human IL-17A Precoated ELISA Kit

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