Human IL-8 Precoated ELISA Kit
$499.00
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Key Features
✓ Assay Range: 31.3-2000 pg/mL
✓ Sensitivity: 25 pg/mL
✓ Sample Types: Serum, Plasma, Cell Culture Supernates
Size
✓ 1 Kit (96 well plate)
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Product Details
Storage & Preparation
Data Images
Background
Product Documents
Product Details
| Product Type | Quantitative ELISA, Colorimetric |
| Product Summary |
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| Reactivity | Human IL-8
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| Product Components |
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Storage & Preparation
| Shipping | Shipped on blue ice |
| Stability & Storage | Store the unopened kit at 2-8℃, The kit is stable for 12 months. Do not use beyond expiration date. |
| Reconstitution | See Datasheet for Component Preparation |
Data Images
Human IL-8 ELISA standard curve, typical data. User-generated standard curve is required for each set of samples. Please refer to protocol.
Background
| Alternative Names | Interleukin-8, IL8, Granulocyte chemotatic protein 1, GCP1, C-X-C motif chemokin 8, LECT, LUCT, LYNAP, T cell chemotactic factor, TCF, TSG1, Neutrophil-activating protein 1,MDNCF, MONAP, NAF, NAP1, NCF |
| Function | IL-8 (CXCL8) is a chemokine that plays a pivotal role in orchestrating the innate immune response and inflammation. It is primarily involved in recruiting and activating neutrophils to sites of infection or tissue damage. IL-8 is secreted by a range of cells—including macrophages, endothelial cells, and epithelial cells—in response to inflammatory stimuli. Upon release, IL-8 binds to its G protein-coupled receptors, CXCR1 and CXCR2, on target cells, triggering signaling pathways that promote chemotaxis, degranulation, and the respiratory burst in neutrophils. Beyond its role in immune cell recruitment, IL-8 also contributes to angiogenesis and tissue remodeling, processes that are important in wound healing and may influence tumor progression. |
| Tissue Specificity | IL-8 expression has been reported in macrophages, epithelial, endothelial cells, and fibroblasts. |
| Cellular Localization | Secreted |
| Involvement in Disease | Dysregulation of IL-8 is implicated in inflammatory disorders such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease, in addition to acute inflammatory states such as sepsis and acute respiratory distress syndrome (ARDS), where increased IL-8 drives excessive recruitment and activation of neutrophils, contributing to tissue damage. IL-8 is also implicated in Chronic lung conditions, including cystic fibrosis and chronic obstructive pulmonary disease (COPD); and atherosclerosis and other vascular inflammatory disorders. IL-8 promotes tumor growth, angiogenesis, and metastasis by shaping the tumor microenvironment and has been reported in various malignancies—including lung, colon, prostate, and breast cancers. |
| UniProt | P10145 |
| Gene Symbol | CXCL8 |
| Entrez Gene ID | 3576 |
Product Documents
| Product Datasheet | Download Product Datasheet |
| COA | Contact Us |
| SDS | Contact Us |
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