Product Type	Quantitative ELISA, Colorimetric
Product Summary	Assay Range: 15.6-1000 pg/mL Sensitivity: 5 pg/mL Sample Types: Serum, Plasma, Cell Culture Supernates Intra-Assay Precision: ≤10% Inter-Assay Precision: ≤15%
Reactivity	Human MCP-1 No cross-reactivity with human cytokines
Product Components	Human MCP-1 Coated Microplate, 96 well (8 x12 strips) Human MCP-1 Standard, 2 vials Human MCP-1 Biotinylated Antibody, 2 vials Streptavidin-HRP, 2 vials Dilution Buffer, 3 bottles Washing Buffer, 1 bottle Color Reagent (TMB), 1 bottle Stop Solution, 1 bottle Plate Sealers, 4 strips Other materials required: See Datasheet

Shipping	Shipped on blue ice
Stability & Storage	Store the unopened kit at 2-8℃, The kit is stable for 12 months. Do not use beyond expiration date.
Reconstitution	See Datasheet for Component Preparation

Alternative Names	Monocyte chemoattractant protein-1, MCP-1, C-C motif chemokine 2, CCL2, Small-inducible cytokine A2, SCYA2, HC11, HSMCR30, Monocyte chemotactic and activating factor, MCAF
Function	MCP-1, also known as CCL2, is a chemokine involved in recruiting monocytes, memory T cells, and dendritic cells to sites of tissue injury and inflammation, initiating and sustaining inflammatory responses, as well as tissue repair and remodeling. MCP-1 binds to CCR2, a G protein-coupled receptor (GPCR).
Tissue Specificity	MCP-1 is widely expressed in cells and tissues involved in the inflammatory response and recruitment of monocytes and immune cells to sites of tissue damage or infection. MCP-1 expression has been reported in endothelial cells (vascular tissue), epithelial cells (lung, kidney, gastrointestinal tissue), smooth muscle cells (blood vessels, gastrointestinal tissue), and fibroblasts.
Cellular Localization	Secreted
Involvement in Disease	Dysregulation of MCP-1 is reported in cardiovascular diseases (atherosclerosis, myocardial infarction), autoimmune and inflammatory diseases (rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease), metabolic disorders (obesity, type 2 diabetes, non-alcoholic fatty liver disease [NAFLD]), neurogenerative diseases (Alzheimer’s disease, Parkinson’s disease), stroke, fibrotic diseases and cancer (tumor microenvironment, metastasis).
UniProt	P13500
Gene Symbol	CCL2
Entrez Gene ID	6347

Human MCP-1 Precoated ELISA Kit

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