Product Type	Quantitative ELISA, Colorimetric
Product Summary	Assay Range: 31.3-2000 pg/mL Sensitivity: 15 pg/mL Sample Types: Serum, Plasma, Cell Culture Supernates Intra-Assay Precision: ≤10% Inter-Assay Precision: ≤15%
Reactivity	Human MIP-1 alpha No cross-reactivity with human cytokines
Product Components	Human MIP-1 alpha Coated Microplate, 96 well (8 x12 strips) Human MIP-1 alpha Standard, 2 vials Human MIP-1 alpha Biotinylated Antibody, 2 vials Streptavidin-HRP, 2 vials Dilution Buffer, 3 bottles Washing Buffer, 1 bottle Color Reagent (TMB), 1 bottle Stop Solution, 1 bottle Plate Sealers, 4 strips Other materials required: See Datasheet

Shipping	Shipped on blue ice
Stability & Storage	Store the unopened kit at 2-8℃, The kit is stable for 12 months. Do not use beyond expiration date.
Reconstitution	See Datasheet for Component Preparation

Alternative Names	CCL3, C-C Motif Chemokine 3, Macrophage Inflammatory Protein 1-alpha, MIP1A, Small-inducible Cytokine A3, SCYA3, SIS-beta, Tonsillar Lymphocyte LD78 alpha Protein, LD78a
Function	Human MIP-1 alpha (macrophage inflammatory protein-1 alpha), also known as CCL3, is a member of the CC chemokine family. MIP-1 alpha exerts chemotactic properties on monocytes, T lymphocytes, and dendritic cells to sites of infection or injury. MIP-1α primarily exerts its effects by binding to G protein-coupled receptors (GPCRs), particularly CCR1 and CCR5.
Tissue Specificity	MIP-1 alpha is primarily secreted by macrophages and monocytes, with secretion noted in dendritic cells, activated T cells and natural killer (NK) cells. MIP-1 alpha expression has been reported in lymph nodes, spleen, bone marrow, lung tissue, liver tissue, and synovial tissues.
Cellular Localization	Secreted protein
Involvement in Disease	Dysregulation of MIP-1 alpha has been reported in autoimmune and inflammatory disorders (rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis), HIV, tumor microenvironment, neuroinflammation, asthma, and chronic obstructive pulmonary disease (COPD).
UniProt	P10147
Gene Symbol	CCL3
Entrez Gene ID	6348

Human MIP-1 alpha Precoated ELISA Kit

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