Human TGF-beta 1 Precoated ELISA Kit
$499.00
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Key Features
✓ Assay Range: 31.3-2000 pg/mL
✓ Sensitivity: 15 pg/mL
✓ Sample Types: Serum, Plasma, Cell Culture Supernates
Size
✓ 1 Kit (96 well plate)
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Product Details
Storage & Preparation
Data Images
Background
Product Documents
Product Details
| Product Type | Quantitative ELISA, Colorimetric |
| Product Summary |
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| Reactivity | Human TGF-beta 1
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| Product Components |
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Storage & Preparation
| Shipping | Shipped on blue ice |
| Stability & Storage | Store the unopened kit at 2-8℃, The kit is stable for 12 months. Do not use beyond expiration date. |
| Reconstitution | See Datasheet for Component Preparation |
Data Images
Human TGF-beta 1 ELISA standard curve, typical data. User-generated standard curve is required for each set of samples. Please refer to protocol.
Background
| Alternative Names | Transforming Growth Factor beta 1, TGFB, TGFB1, Prepro-Transforming Growth Factor Beta-1, Latency-Associated Peptide, LAP, CED, DPD1 |
| Function | Transforming Growth Factor-beta 1 (TGF-beta 1) is a multifunctional cytokine expressed in virtually all tissue types. Regulation of TGF-beta 1 expression occurs by the proteolytic processing of the preproprotein, where a latent complex consisting of a latency-associated peptide (LAP) homodimer, mature peptide homodimer and latent TGF-beta binding protein (LTBP) form and remain in the extracellular matrix. Interactions with the activation pathway release the mature TGF-beta 1 homodimer that is a ligand for a heterodimeric complex composed of TGF-beta RII and either TGF-beta RI or ALK-1. TGF-beta 1 was initially isolated from platelets where it plays a role in wound healing through proliferation of fibroblasts and activation of pathways for extracellular matrix synthesis of collagens and proteoglycans. TGF-beta 1 is involved in the regulation of the immune response through the induction of Th17 or Treg cells based on concentrations within the microenvironment. |
| Tissue Specificity | TGF-beta 1 expression is almost ubiquitous in all tissue types in concert with the wide-range of functions in wound healing, developmental cell patterning, regulation of epithelial and endothelial tissues, angiogenesis, bone remodeling, neuroprotection, and inflammatory regulation. |
| Cellular Localization | Secreted protein as both a latent protein complex in the extracellular matrix and activated mature protein. |
| Involvement in Disease | TGF-beta 1 plays an important role as a cancer tumor suppressor, however, dysregulation of TGF-beta 1 can promote tumor growth, metastasis and immune evasion that is associated with various cancers, including breast cancer, colorectal cancer, pancreatic cancer, and prostate cancer. Dysregulated TGF-β1 has been implicated in autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and inflammatory bowel diseases. |
| UniProt | P01137 |
| Gene Symbol | TGFB1 |
| Entrez Gene ID | 7040 |
Product Documents
| Product Datasheet | Download Product Datasheet |
| COA | Contact Us |
| SDS | Contact Us |
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