Biological Activity	Determined by in-house activity assay
Purity	Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining
Endotoxin	Determined by LAL method
Expression System	E. coli.
Accession Number	P12643
Sequence	Gln283-Arg396, with an N-terminal Met MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR
Molecular Weight	13 kDa (monomer, predicted)
Formulation	Lyophilized from sterile PBS with Trehalose, pH 7.4

Shipping	Shipped at ambient temperature.
Stability & Storage	12 months from date of receipt at -20°C to -70°C, lyophilized powder. 3 months at -20°C to -70°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw cycles.
Reconstitution	Reconstitute at 100 ug/mL in sterile PBS.

Alternative Names	Bone Morphogenetic Protein 2, Bone Morphogenetic Protein 2A, BMP2, BMP2A, BDA2, SSFSC, SSFSC1
Function	Bone Morphogenetic Protein 2 (BMP-2) mediates several functions related to cartilage and bone formation. During embryonic development, BMP-2 contributes to dorsal-ventral patterning of the developing neural tube, and influences differentiation of endoderm, mesenchymal cells, and chondrocytes. In response to tissue damage, BMP-2 promotes chondrogenesis, migration of keratinocytes, and angiogenesis. BMP-2 signaling occurs via binding to BMPR1A (CD292) and BMPR2, at which point BMPR2 transphosphorylates BMPR1A to induce the Smad signaling pathway.
Tissue Specificity	BMP-2 expression has been identified in ectoderm, mesoderm, endoderm, developing skeletal tissues such as cartilage and bone, the developing central nervous system, including the neural tube and the brain, heart, kidney, lung, and skin.
Cellular Localization	Secreted protein
Involvement in Disease	Dysregulation of BMP-2 is associated with osteoporosis, atherosclerosis, congenital heart defects, Alzheimer’s disease, Parkinson’s disease, insulin resistance, type 2 diabetes, osteoarthritis, and various cancers due to BMP-2 enhanced invasion and metastasis of cancer cells.
UniProt	P12643
Gene Symbol	BMP2
Entrez Gene ID	650

Recombinant Human BMP-2 Protein

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