Biological Activity	Determined by in-house activity assay
Purity	Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining
Endotoxin	Determined by LAL method
Expression System	E. coli.
Accession Number	O14944
Sequence	Val60-Leu108, with an N-terminal Met MVAQVSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFFL
Molecular Weight	5.7 kDa (predicted)
Formulation	Lyophilized from sterile PBS with Trehalose, pH 7.4

Shipping	Shipped at ambient temperature.
Stability & Storage	12 months from date of receipt at -20°C to -70°C, lyophilized powder. 3 months at -20°C to -70°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw cycles.
Reconstitution	Reconstitute at 100 ug/mL in sterile PBS.

Alternative Names	EREG, Proepiregulin
Function	Epiregulin is a widely expressed growth factor involved in cell growth, proliferation, differentiation, and tissue repair. Epiregulin is expressed by peripheral blood macrophages and normal keratinocytes in response to tissue damage which promotes inflammation, angiogenesis and fibroblast-mediated wound healing. Epiregulin is also produced in the placenta, uterus and during ovarian follicle formation. Epiregulin promotes the proliferation of smooth muscle cells and hepatocytes. Signaling by Epiregulin occurs with the binding of EGFR (ErbB1) or ErbB4.
Tissue Specificity	Epiregulin expression has been identified in skin, gastrointestinal tract, respiratory tract, ovaries, uterus, placenta, liver, brain, kidney, pancreas, and adipose tissues.
Cellular Localization	Membrane-bound and cleaved soluble protein forms
Involvement in Disease	Dysregulation of Epiregulin is associated with atherosclerosis, cardiac hypertrophy, polycystic ovary syndrome (PCOS), psoriasis, atopic dermatitis, inflammatory bowel disease (IBD), rheumatoid arthritis, and various cancers (breast cancer, colorectal cancer, lung cancer, ovarian cancer) due to tumor growth and metastasis.
UniProt	O14944
Gene Symbol	EREG
Entrez Gene ID	2069

Recombinant Human Epiregulin Protein

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