Biological Activity	Determined by in-house activity assay
Purity	Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining
Endotoxin	Determined by LAL method
Expression System	E. coli.
Accession Number	O15520
Sequence	Cys37-Ser208, with an N-terminal Met MCQALGQDMV SPEATNSSSS SFSSPSSAGR HVRSYNHLQG DVRWRKLFSF TKYFLKIEKN GKVSGTKKEN CPYSILEITS VEIGVVAVKA INSNYYLAMN KKGKLYGSKE FNNDCKLKER IEENGYNTYA SFNWQHNGRQ MYVALNGKGA PRRGQKTRRK NTSAHFLPMV VHS
Molecular Weight	19.5 kDa (predicted)
Formulation	Lyophilized from sterile PBS with Trehalose, pH 7.4

Shipping	Shipped at ambient temperature.
Stability & Storage	12 months from date of receipt at -20°C to -70°C, lyophilized powder. 3 months at -20°C to -70°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw cycles.
Reconstitution	Reconstitute at 100 ug/mL in sterile PBS.

Alternative Names	Fibroblast Growth Factor 10, Keratinocyte Growth Gactor 2, KGF2
Function	Fibroblast Growth Factor 10 (FGF-10) is a protein involved in various developmental processes, particularly in embryogenesis and tissue regeneration. FGF-10 promotes branching morphogenesis of branched structures in several organs, including lungs, salivary glands, skin, pancreas, and mammary glands. Additionally, FGF-10 stimulates angiogenesis in during embryonic development, the maintenance of stem cell populations and facilitates tissue repair. FGF-10 primarily binds to FGF Receptor 2B (FGFR2B).
Tissue Specificity	Lungs, salivary glands, skin, pancreas, inner ear, prostate and mammary glands.
Cellular Localization	Secreted protein
Involvement in Disease	Aberrant FGF-10 signaling has been implicated in several lung diseases, including pulmonary fibrosis, chronic obstructive pulmonary disease (COPD), and lung cancer. Dysregulated FGF-10 expression or signaling pathways can disrupt lung development and repair processes. Elevated FGF-10 expression or aberrant activation of FGF receptors (FGFRs) have been implicated in pancreatic, breast and prostate cancer tumor growth and metastasis.
UniProt	O15520
Gene Symbol	FGF10
Entrez Gene ID	2255

Recombinant Human FGF-10 Protein

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