Recombinant Human GM-CSF/CSF2 Protein
$90.00 – $3,499.00
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Key Features
✓ Endotoxin Level: Determined by LAL method
✓ Purity: Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining
✓ Biological Activity: Yes
✓ Expression System: E. coli
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Product Details
Storage & Preparation
Data Images
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Product Documents
Product Details
| Biological Activity | Determined by in-house activity assay |
| Purity | Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining |
| Endotoxin | Determined by LAL method |
| Expression System | E. coli. |
| Accession Number | P04141 |
| Sequence | Ala18-Glu144, with an N-terminal Met MAPARSPSPS TQPWEHVNAI QEARRLLNLS RDTAAEMNET VEVISEMFDL QEPTCLQTRL ELYKQGLRGS LTKLKGPLTM MASHYKQHCP PTPETSCATQ IITFESFKEN LKDFLLVIPF DCWEPVQE |
| Molecular Weight | 14.6 kDa (predicted) |
| Formulation | Lyophilized from sterile PBS with Trehalose, pH 7.4 |
Storage & Preparation
| Shipping | Shipped at ambient temperature. |
| Stability & Storage |
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| Reconstitution | Reconstitute at 100 ug/mL in sterile PBS. |
Data Images
Background
| Alternative Names | Granulocyte Macrophage Growth Factor, CSF2, Sargramostim, Molgramostim, Colony Stimulating Factor 2, Pluripoietin-a, MGI-IGM, Csfgm |
| Function | Granulocyte Macrophage Growth Factor (GM-CSF), also known as CSF2, is a cytokine with diverse biological functions, primarily related to immune and inflammatory responses. In addition to a role in maintaining a niche environment for hematopoietic stems cells, GM-CSF stimulates the growth and differentiation of hematopoietic progenitor cells from various lineages including granulocytes (neutrophils, eosinophils, and basophils) and macrophages. The production of GM-CSF by T cells, macrophages, dendritic cells, B cells, eosinophils, and mast cells leads to the differentiation and activation of various immune cells, including macrophages and dendritic cells. Activation of dendritic cells and T cells involving GM-CSF plays a role in the native anti-tumor immune response, which has led to immunotherapies such as chimeric antigen receptor (CAR) T cell therapy. GM-CSF is also involved in enhancement of antibody production by B cells, the Th1 polarized immune response, and tissue repair and remodeling processes. GM-CSF binds a receptor complex composed of the GM-CSF R alpha (CD116) and common beta chain (CD131). |
| Tissue Specificity | Bone marrow stromal cells, lymph node, spleen, vascular endothelial cells, respiratory and gastrointestinal epithelial cells, and fibroblasts. |
| Cellular Localization | Secreted protein |
| Involvement in Disease | Dysregulation of GM-CSF production is implicated in autoimmune disorders (rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease), cancer tumor progression, cancer immune evasion, leukemia, myelodysplastic syndromes, pulmonary alveolar proteinosis (PAP), allergic inflammation (asthma, atopic dermatitis) and neuroinflammatory processes in Alzheimer’s disease and Parkinson’s disease. |
| UniProt | P04141 |
| Gene Symbol | CSF2 |
| Entrez Gene ID | 1437 |
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