Recombinant Human IFN-gamma Protein
$90.00 – $1,129.00
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Key Features
✓ Endotoxin Level: Determined by LAL method
✓ Purity: Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining
✓ Biological Activity: Yes
✓ Expression System: E. coli
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Product Details
Storage & Preparation
Data Images
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Product Documents
Product Details
| Biological Activity | Determined by in-house activity assay |
| Purity | Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining |
| Endotoxin | Determined by LAL method |
| Expression System | E. coli. |
| Accession Number | P01579 |
| Sequence | Gln24-Gln166, with an N-terminal Met MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ |
| Molecular Weight | 16.9 kDa (predicted) |
| Formulation | Lyophilized from sterile PBS with Trehalose, pH 7.4 |
Storage & Preparation
| Shipping | Shipped at ambient temperature. |
| Stability & Storage |
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| Reconstitution | Reconstitute at 100 ug/mL in sterile PBS. |
Data Images
Background
| Alternative Names | Interferon gamma, IFNG, Immune Interferon, IFG, IFI |
| Function | Interferon-gamma (IFN-gamma) is a protein with predominant roles in the innate and adaptive immune response. It is secreted by Th1 cells, cytotoxic T cells, macrophages, dendritic cells, mucosal epithelial cells and NK cells. IFN-gamma promotes the differentiation of T cells into Th1 cells. Th1 cells produce IFN-gamma themselves, creating a positive feedback loop that amplifies the immune response. In addition, IFN-gamma upregulates monocytes, macrophages, and dendritic cells while increasing MHC class I and II expression. B Cell immunoglobulin class switching is also influenced by IFN-gamma. IFN-gamma RI (CD119/IFNGR1) is the ligand-binding subunit that heterodimerizes with the IFN-gamma RII (IFNGR2). |
| Tissue Specificity | IFN-gamma expression has been identified in vascular endothelial cells, respiratory and gastrointestinal epithelial cells. |
| Cellular Localization | Secreted protein |
| Involvement in Disease | Dysregulation of IFN-gamma is associated with autoimmune disorders (multiple sclerosis (MS), rheumatoid arthritis (RA), type 1 diabetes, and inflammatory bowel diseases (IBD)), allergic asthma, atherosclerosis, hemophagocytic lymphohistiocytosis (HLH), Alzheimer’s disease, Parkinson’s disease and multiple sclerosis (MS). |
| UniProt | P01579 |
| Gene Symbol | IFNG |
| Entrez Gene ID | 3458 |
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