Recombinant Human IL-3 Protein
$90.00 – $3,199.00
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Key Features
✓ Endotoxin Level: Determined by LAL method
✓ Purity: Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining
✓ Biological Activity: Yes
✓ Expression System: E. coli
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Product Details
Storage & Preparation
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Product Documents
Product Details
| Biological Activity | Determined by in-house activity assay |
| Purity | Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining |
| Endotoxin | Determined by LAL method |
| Expression System | E. coli. |
| Accession Number | P08700 |
| Sequence | Ala20-Phe152 APMTQTTSLK TSWVNCSNMI DEIITHLKQP PLPLLDFNNL NGEDQDILME NNLRRPNLEA FNRAVKSLQN ASAIESILKN LLPCLPLATA APTRHPIHIK DGDWNEFRRK LTFYLKTLEN AQAQQTTLSL AIF |
| Molecular Weight | 15 kDa (predicted) |
| Formulation | Lyophilized from sterile PBS with Trehalose, pH 7.4 |
Storage & Preparation
| Shipping | Shipped at ambient temperature. |
| Stability & Storage |
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| Reconstitution | Reconstitute at 100 ug/mL in sterile PBS. |
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| Alternative Names | Interleukin 3, IL3, Mast Cell Growth Factor, Multilineage Colony Stimulating Factor, Multipotential Colony Stimulating Factor, Hematopoietic Growth Factor, P-Cell Stimulating Factor, MULTI-CSF, MCGF, MGC79398, MGC79399 |
| Function | Interleukin-3 (IL-3) is a pleiotropic cytokine that plays a crucial role in the proliferation, differentiation, and survival of hematopoietic stem cells and myeloid progenitor cells. In particular, IL-3 regulates the development of basophils, dendritic cells, eosinophils, erythrocytes, macrophages, mast cells, megakaryocytes, monocytes, and neutrophils. IL-3 is produced by a variety of cells, including activated T cells, B cells, mast cells, and vascular endothelial cells. Signaling takes place through binding to IL-3R alpha (CD123) that heterodimerizes with the common beta chain (CD131). |
| Tissue Specificity | IL-3 expression has been identified in bone marrow stromal cells and vascular endothelial tissue. |
| Cellular Localization | Secreted protein |
| Involvement in Disease | Dysregulation of IL-3 is associated with asthma, allergic rhinitis, atopic dermatitis, acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), aplastic anemia, multiple sclerosis (MS), rheumatoid arthritis, systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), psoriasis, rheumatoid arthritis, and myelodysplastic syndromes (MDS). |
| UniProt | P08700 |
| Gene Symbol | IL3 |
| Entrez Gene ID | 3562 |
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