Biological Activity	Determined by in-house activity assay
Purity	Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining
Endotoxin	Determined by LAL method
Expression System	E. coli.
Accession Number	P13232
Sequence	Asp26-His177, with an N-terminal Met MDCDIEGKDG KQYESVLMVS IDQLLDSMKE IGSNCLNNEF NFFKRHICDA NKEGMFLFRA ARKLRQFLKM NSTGDFDLHL LKVSEGTTIL LNCTGQVKGR KPAALGEAQP TKSLEENKSL KEQKKLNDLC FLKRLLQEIK TCWNKILMGT KEH
Molecular Weight	17.5 kDa (predicted)
Formulation	Lyophilized from sterile PBS with Trehalose, pH 7.4

Shipping	Shipped at ambient temperature.
Stability & Storage	12 months from date of receipt at -20°C to -70°C, lyophilized powder. 3 months at -20°C to -70°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw cycles.
Reconstitution	Reconstitute at 100 ug/mL in sterile PBS.

Alternative Names	Interleukin 7, IL7
Function	Interleukin 7 (IL-7) functions in regulating hematopoeitic stem cell differentiation into lymphoid progenitor cells. IL-7 also plays a role in the proliferation and survival of B cells, T cells and NK cells in the lymphoid lineage. This is led to further developments in applying IL-7 in cell culture and manufacturing strategies in cancer immunotherapy approaches, such as adoptive cell therapy (ACT) and chimeric antigen receptor (CAR) T cell therapy.
Tissue Specificity	IL-7 is primarily produced by stromal cells in the bone marrow and thymus with expression also reported in lymph nodes, spleen, intestinal goblet cells, keratinocytes, lung epithelium and liver sinusoidal endothelial cells.
Cellular Localization	Secreted protein
Involvement in Disease	Dysregulation of IL-7 has been implicated in autoimmune diseases (rheumatoid arthritis, multiple sclerosis, Crohn’s disease, ulcerative colitis), aplastic anemia myelodysplastic syndromes, asthma and chronic obstructive pulmonary disease (COPD), Graft-versus-Host Disease (GVHD), and hematological malignancies (acute lymphoblastic leukemia, T cell lymphoma).
UniProt	P13232
Gene Symbol	IL7
Entrez Gene ID	3574

Recombinant Human IL-7 Protein

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