Recombinant Human M-CSF/CSF1 Protein
$90.00 – $4,599.00
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Key Features
✓ Endotoxin Level: Determined by LAL method
✓ Purity: Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining
✓ Biological Activity: Yes
✓ Expression System: Mammalian cell line
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Product Details
Storage & Preparation
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Product Documents
Product Details
| Biological Activity | Determined by in-house activity assay |
| Purity | Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining |
| Endotoxin | Determined by LAL method |
| Expression System | Mammalian cell line. |
| Accession Number | P09603 |
| Sequence | Glu33-Arg255 EEVSEYCSHM IGSGHLQSLQ RLIDSQMETS CQITFEFVDQ EQLKDPVCYL KKAFLLVQDI MEDTMRFRDN TPNAIAIVQL QELSLRLKSC FTKDYEEHDK ACVRTFYETP LQLLEKVKNV FNETKNLLDK DWNIFSKNCN NSFAECSSQD VVTKPDCNCL YPKAIPSSDP ASVSPHQPLA PSMAPVAGLT WEDSEGTEGS SLLPGEQPLH TVDPGSAKQR PPR |
| Molecular Weight | 25.1 kDa (monomer,predicted) |
| Formulation | Lyophilized from sterile PBS with Trehalose, pH 7.4 |
Storage & Preparation
| Shipping | Shipped at ambient temperature. |
| Stability & Storage |
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| Reconstitution | Reconstitute at 100 ug/mL in sterile PBS. |
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| Alternative Names | Macrophage Colony Stimulating Factor, CSF1, CSF-1, MCSF, MGC31930, Lanimostim, PG-M-CSF, Proteoglycan Macrophage Colony Stimulating Factor |
| Function | Macrophage Colony-stimulating Factor (M-CSF), also known as CSF-1, is a cytokine with roles in the growth, differentiation, and survival of monocytes and macrophages. M-CSF promotes the differentiation of monocytes into mature tissue-resident macrophages involved in the phagocytosis of pathogens, clearance of debris, and secretion of growth factors for tissue repair. In addition, M-CSF is involved in regulating bone homeostasis by stimulating osteoclast differentiation and activity. M-CSF is primarily produced by monocytes and macrophages themselves. It acts in an autocrine and paracrine manner to regulate the proliferation, differentiation, and survival of these cells. However, M-CSF is also produced in bone marrow stromal cells, fibroblasts and endothelial cells as a component in the local microenvironmental regulation of the immune cell function. M-CSF is often highly expressed in the tumor microenvironment where it recruits tumor-associated macrophages (TAMs) that suppress the native immune response leading to tumor progression and infiltration. M-CSF binds M-CSF R (CD115), a Receptor Tyrosine Kinase (RTK) family III member. |
| Tissue Specificity | Bone marrow stromal cells, spleen, vascular endothelial cells, endometrial secretory epithelium, respiratory and gastrointestinal epithelial cells, and synovial fibroblasts. |
| Cellular Localization | Membrane-bound and cleaved soluble protein forms |
| Involvement in Disease | Dysregulation of M-CSF is implicated in autoimmune disorders (rheumatoid arthritis, atherosclerosis, inflammatory bowel disease), osteoporosis, cancer tumor progression, cancer immune evasion, monocytic leukemia and neuroinflammatory processes in Alzheimer’s disease and multiple sclerosis. |
| UniProt | P09603 |
| Gene Symbol | CSF1 |
| Entrez Gene ID | 1435 |
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