Biological Activity	Determined by in-house activity assay
Purity	Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining
Endotoxin	Determined by LAL method
Expression System	E. coli.
Accession Number	P23560
Sequence	His129-Arg247, with an N-terminal Met MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
Molecular Weight	13.6 kDa (predicted)
Formulation	Lyophilized from sterile PBS with Trehalose, pH 7.4

Shipping	Shipped at ambient temperature.
Stability & Storage	12 months from date of receipt at -20°C to -70°C, lyophilized powder. 3 months at -20°C to -70°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw cycles.
Reconstitution	Reconstitute at 100 ug/mL in sterile PBS.

Alternative Names	Brain-derived Neurotrophic Factor, Neurotrophin, Abrineurin, ANON2, BULN2
Function	Brain-Derived Neurotrophic Factor (BDNF) is a protein that plays a crucial role in the development, growth, maintenance, and survival of neurons. BDNF regulates neurogenesis of new neurons from neural stem cells by promoting axon and dendritic growth. BDNF enhances neuroprotection and regulates synaptic plasticity in mature neurons, thus affecting aspects of mood regulation, learning, memory and other cognitive functions. BDNF binds to TrkB as the high affinity signaling receptor, but association with the low-affinity p75-NTR has been reported.
Tissue Specificity	BDNF expression has been reported in brain (hippocampus, cortex, and basal forebrain), peripheral nerves, heart, skeletal muscle, adipose tissue, liver, thymus, and lung.
Cellular Localization	Secreted protein
Involvement in Disease	Dysregulation of BDNF has been associated with bipolar disorder, depression, Alzheimer’s disease, Parkinson’s disease, and epilepsy.
UniProt	P23560
Gene Symbol	BDNF
Entrez Gene ID	627

Recombinant Human/Mouse/Rat BDNF Protein

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