Recombinant Human SCF Protein
$90.00 – $2,499.00
In-stock products will arrive in 1 to 2 business days
Key Features
✓ Endotoxin Level: Determined by LAL method
✓ Purity: Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining
✓ Biological Activity: Yes
✓ Expression System: E. coli
Need Help Ordering?
Product Details
Storage & Preparation
Data Images
Background
Product Documents
Product Details
| Biological Activity | Determined by in-house activity assay |
| Purity | Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining |
| Endotoxin | Determined by LAL method |
| Expression System | E. coli. |
| Accession Number | P21583 |
| Sequence | Glu26-Ala189, with an N-terminal Met MEGICRNRVT NNVKDVTKLV ANLPKDYMIT LKYVPGMDVL PSHCWISEMV VQLSDSLTDL LDKFSNISEG LSNYSIIDKL VNIVDDLVEC VKENSSKDLK KSFKSPEPRL FTPEEFFRIF NRSIDAFKDF VVASETSDCV VSSTLSPEKD SRVSVTKPFM LPPVA |
| Molecular Weight | 18.6 kDa (predicted) |
| Formulation | Lyophilized from sterile PBS with Trehalose, pH 7.4 |
Storage & Preparation
| Shipping | Shipped at ambient temperature. |
| Stability & Storage |
|
| Reconstitution | Reconstitute at 100 ug/mL in sterile PBS. |
Data Images
Background
| Alternative Names | Stem Cell Factor, SCF, Mast Cell Growth Factor, DFNA69, Kit Ligand, KITLG, C-Kit Ligand, MGF, Steel Factor, Kitl, KL-1, FPH2, SLF, SHEP7, DCUA, FPHH, WS2F |
| Function | Stem Cell Factor (SCF) plays an important role acting on progenitor cells in hematopoiesis, germ cell development, and melanogenesis. SCF not only has a role in expansion and differentiation of stem cells but is an important factor in preventing apoptosis and promoting self-renewal and survival of stem cells. The receptor for SCF is c-KIT (CD117). c-Kit expression is lost during differentiation of hematopoietic cells, with the exception of mast cells. SCF induces mast cell proliferation and histamine release. |
| Tissue Specificity | SCF expression has been reported in skin (particularly in basal layer of the epidermis), stomach, intestines, testes, ovaries, brain, thymus and lymph nodes. |
| Cellular Localization | Membrane-bound and cleaved soluble protein forms |
| Involvement in Disease | Dysregulation of SCF has been implicated in gastrointestinal stromal tumors (GISTs), leukemia, melanomas, breast cancer, aplastic anemia, myelodysplastic syndromes, mastocytosis, pigmentation disorders (piebaldism and Waardenburg syndrome), gonadal dysgenesis, inflammatory bowel disease (IBD), Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and allergic asthma. |
| UniProt | P21583 |
| Gene Symbol | KITLG |
| Entrez Gene ID | 4254 |
Reviews
There are no reviews yet.