Biological Activity	Determined by in-house activity assay
Purity	Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining
Endotoxin	Determined by LAL method
Expression System	E. coli.
Accession Number	P15692
Sequence	Ala27-Arg191 APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENPCGPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR
Molecular Weight	19.7 kDa (predicted)
Formulation	Lyophilized from sterile PBS with Trehalose, pH 7.4

Shipping	Shipped at ambient temperature.
Stability & Storage	12 months from date of receipt at -20°C to -70°C, lyophilized powder. 3 months at -20°C to -70°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw cycles.
Reconstitution	Reconstitute at 100 ug/mL in sterile PBS.

Alternative Names	Vascular Endothelial Growth Factor, VEGF-A, Vascular Permeability Factor, VPF, MVCD1
Function	Vascular endothelial growth factor (VEGF) is involved in angiogenesis, vasculogenesis, neurogenesis and endothelial cell growth during embryonic development and in adults. It induces endothelial cell proliferation, migration, and permeabilization of blood vessels. VEGF is upregulated during hypoxia, inflammation, tissue repair and during neovascularization of tumors and adipose tissue. Additionally, VEGF induces neural progenitor cell proliferation and regulates mesenchymal stem cell differentiation. VEGF binds to the VEGFR1 (FLT1) and VEGFR2 (KDR/CD309) receptors, however, Neuropilin-1 will also bind VEGF as a coreceptor for VEGFR2.
Tissue Specificity	VEGF expression has been reported in vascular endothelial cells, ovaries, adipose tissue, skeletal muscle and most tumors.
Cellular Localization	Secreted protein
Involvement in Disease	VEGF dysregulation is implicated in macular degeneration, diabetic retinopathy, rheumatoid arthritis, psoriasis, and cancer.
UniProt	P15692
Gene Symbol	VEGFA
Entrez Gene ID	7422

Recombinant Human VEGF 165 Protein

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