Proteins for Organoid Culture
Organoids are three-dimensional (3D) structures grown from stem cells that mimic the organization and functionality of real organs. These miniature, simplified versions of organs can replicate key features of their in vivo counterparts, such as cellular diversity, spatial architecture, and specific functions. Organoids are typically generated from adult stem cells, tissue samples containing adult stem cells, or induced pluripotent stem cells (iPSCs).
We have highlighted our cytokines and growth factors for organoid culture below. Our proteins are tested to confirm high bioactivity, exceptional purity, and low endotoxin levels.
| Activin A | BMP-2 | BMP-4 | EGF |
| FGF-10 | FGF-basic/FGF-2 | HGF | KGF/FGF-7 |
| Noggin/NOG | R-Spondin 1/RSPO1 | R-Spondin 3/RSPO3 | Wnt3A |
Characteristics of Organoids
- Self-Organization: Organoids can self-organize into structures resembling specific organs or tissues.
- Diverse Cell Types: They consist of multiple cell types found in the organ they mimic.
- Functionality: They exhibit functional properties similar to the organ, such as hormone secretion, response to stimuli, or electrical activity.
- Scalability: Organoids can be scaled up for high-throughput screening and other large-scale studies.
Applications in Research
- Disease Modeling: Organoids can replicate the pathology of diseases, allowing researchers to study disease mechanisms in a controlled environment. For example, cancer organoids can be used to understand tumor biology and test anti-cancer drugs.
- Drug Testing and Development: Organoids provide a more accurate model for testing drug efficacy and toxicity compared to traditional 2D cell cultures, leading to better predictions of how drugs will perform in humans.
- Personalized Medicine: Patient-derived organoids can be used to tailor treatments to individuals by testing how their specific organoids respond to different therapies.
- Developmental Biology: Organoids can model human development processes, helping researchers understand how tissues and organs form and differentiate.
- Regenerative Medicine: Insights gained from organoid research can contribute to the development of regenerative therapies, such as growing tissues or organs for transplantation.
- Infectious Diseases: Organoids can be used to study how pathogens infect specific organs and to test potential treatments for infections.
