July 1, 2024
By dev@agencyjet.com

Proteins for Stem Cell Culture

Streamline your stem cell culture with Exreprotein recombinant cytokines and growth factors.

Proteins for Stem Cell Culture

Streamline your stem cell culture with ExreproteinTM recombinant cytokines and growth factors. We prioritize consistent results, rigorously testing our proteins to guarantee robust stem cell expansion and differentiation. Each lot undergoes thorough testing to confirm high bioactivity, exceptional purity, and low endotoxin levels.

Pluripotent Stem Cells

Pluripotent stem cells (PSCs), which include embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), retain the ability to differentiate into the three germ layers: ectoderm mesoderm and endoderm. Their versatility makes them essential in regenerative medicine, disease modeling, drug discovery, and developmental biology research. Culturing PSCs demands precise conditions to maintain their pluripotency and viability for research and therapeutic applications. This process requires highly optimized growth factors and cytokines to promote cell growth and sustain pluripotency.
Activin ABMP-4EGFFGF-basic/FGF-2
Flt-3 Ligand/FLT3LHeregulin beta1LIFNoggin/NOG
R-Spondin-1SCFTGF-beta 1VEGF
Wnt3A   

Ectoderm Differentiation

Ectoderm differentiation from pluripotent stem cells (PSCs) is the initial step required before further terminal differentiation into tissues and cell types derived from the ectodermal germ layer, such as neurons, glial cells, skin cells, and sensory cells.
BMP-4EGFFGF-basic/FGF-2Noggin/NOG

Endoderm Differentiation

Producing definitive endoderm cells from PSCs is a critical step before cells can be differentiated into downstream endoderm lineages such as liver cells, pancreatic cells, intestinal cells, lung cells and thyroid cells.
Activin ABMP-2BMP-4EGF
FGF-10FGF-basic/FGF-2HGFKGF/FGF-7
Noggin/NOGPDGF-BBR-Spondin 1/RSPO1VEGF

Mesoderm Differentiation

Directed differentiation of pluripotent stem cells (PSCs) into mesoderm involves guiding these cells through specific stages to become mesodermal progenitors. Once mesodermal progenitors are obtained, they can be further differentiated into specific mesodermal derivatives such as cardiac muscle cells, skeletal muscle cells, hematopoietic cells, or osteoblasts.

Activin ABMP-2BMP-4EGF
FGF-10FGF-basic/FGF-2Flt-3 Ligand/FLT3LGM-CSF/CSF2
IL-3IL-6KGF/FGF-7M-CSF/CSF1
Noggin/NOGPDGF-BBTRANCE/RANKLR-Spondin 1/RSPO1
SCFTGF-beta 1Thrombopoietin/TpoVEGF

Hematopoeitic Stem Cells

Hematopoietic stem cells (HSCs) are multipotent stem cells giving rise to all blood cell types from both the myeloid and lymphoid lineages. This includes monocytes and macrophages, neutrophils, basophils, eosinophils, erythrocytes, megakaryocytes/platelets, dendritic cells, T cells, B cells, and NK cells. HSCs can be found predominantly in adult bone marrow and to lesser extents in peripheral blood, and umbilical cord blood.

Culturing HSCs requires a precise combination of cytokines and growth factors to support their proliferation, differentiation, and maintenance. The combination and concentration of these cytokines and growth factors can be adjusted to direct HSCs towards specific lineages.

BMP-2BMP-4EGFEpiregulin
FGF-10FGF-basic/FGF-2Flt-3 Ligand/FLT3LGM-CSF/CSF2
IFN-gammaIL-15IL-2IL-3
IL-4IL-6IL-7KGF/FGF-7
M-CSF/CSF1PDGF-BBR-Spondin 1/RSPO1SCF
TGF-beta 1TNF-alphaThrombopoietin/TpoVEGF
Wnt3A   

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells, are multipotent stem cells derived from the mesoderm. They are a heterogeneous population of fibroblast-like cells capable of self-renewal and differentiation into bone, adipose, and cartilage tissue in culture. MSCs are extensively studied in regenerative medicine areas such tissue engineering and wound healing where regenerated cells can improve or resolve disease. Cytokines and growth factors for MSC culture are employed for expansion and directed differentiation into specific lineages in developing therapeutic applications.
BMP-2BMP-4EGFEpiregulin
FGF-10FGF-basic/FGF-2IL-1 beta/IL-1F2IL-6
KGF/FGF-7PDGF-AAPDGF-BBTGF-beta 1
TNF-alpha   

Neural Stem Cells

Neural stem cells (NSCs) are found throughout the developing central nervous system (CNS) as well as in specialized neurogenic regions of the mature CNS. NSCs are capable of self-renewal and differentiation into neurons and glial cells, including oligodendrocytes and astrocytes. NSCs are valuable for neuroscience research and clinical applications, particularly for advancing treatments of neurodegenerative diseases and neurological disorders. NSCs for cell culture are isolated from tissue or differentiated from pluripotent cells using specific cytokines and growth factors to also support proliferation and maintenance.

EGFEpiregulinFGF-10FGF-basic/FGF-2
KGF/FGF-7Neurotrophin 3/NT-3  
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